Agree with you about single issue voting - from my chair, I don't see Roe v Wade ever being overturned. I side with Trump there in believing that it's settled law - as such, voting democrat simply because you are pro choice is a silly position to take IMO (and vice versa for the other side of that argument.)
My top 2 priorities are probably healthcare and education. As someone who grew up in Canada, I don't think single payer is the solution, but there has to be some middle ground. My wife went through cancer treatment in 2016/2017 and thankfully we have good insurance, because it was well into the 6 figures.
Based on what I see, our education system needs an overhaul. I have a son in 9th grade who is not good at math. In interacting with his teacher about his grades, I was informed that "most of the class is failing so they will get an opportunity to reassess." To me, that's a terrible reflection on the teacher and/or curriculum.
Historically, those two issues have been more in the democrat wheelhouse. The democrats answer has been to throw more money at both issues. That hasn't worked all that well especially with education as the U.S. spends more per student than almost any nation. Yet our public system is still lacking compared to others.
As for healthcare, Medicare is the budget item that could ultimately break the bank unless it is reformed. It is nearly impossible for healthcare to be affordable if we are going to offer everyone unlimited end of life treatments. No other 1st world country does that.