It seems to me that the committee has not been a huge fan of putting Louisville and Kentucky into the same regional. They have had that opportunity a time or two, but they've always sent Kentucky elsewhere. They may very well send UK to Louisville this year, but I kind of doubt it. Louisville will almost without a doubt be one of the top 8 seeds. At least at this point they will be. So, if I had to guess they are probably not that likely to get a strong UK team as their two seed. What wouldn't surprise me would be for Minnesota to host and for UK to be sent there. Minny is just barely above UK in the RPI, but they are the only Big 10 school in the top 20 in RPI and I think they will have at least one Big 10 school host.
Right now, it wouldn't surprise me to see:
Florida, South Carolina, and Texas A&M, Ole Miss (Last spot could be several SEC teams)
Louisville, Florida State, Miami, NC State, Clemson
Texas Tech
California
Minnesota
Louisiana Lafayette
UC Santa Barbara
Rice
Coastal Carolina
This way they hit the big conferences (SEC - 5, ACC - 5, Big 12 - 1, Big 10 -1, Pac 12 - 1). Then they get some small schools that are deserving and from difference conferences.