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Revisiting an Older Thread About an Cutting Edge Experiment

CastleRubric

CastleRubric

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Nov 11, 2011
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Let's revisit the British experiment to generate genetically modified mosquitoes
The intent is to reduce certain tropical diseases while patenting their new chimeric products


Here are some links to refresh the source material and basic details of the program:

BBC Genetic Mosquitoes -Florida (2020)

Science Daily - Modified Mosquitoes Take Flight (2021)

Smithsonian - Concerns Raised (2022)

Quick summary & then i will return to edit this down - promise

One reasonable concern expressed was "what happens if the the mutant males DO NOT manage to kill the females" ?

And there are very specific ways that could - and to some degree WILL happen -

Does that create the unfortunate consequence of a new offspring thats - carrying new genetic markers and possibly MORE dangerous?



Good question

Or -- what if back to back to back hurricanes - disrupt or scatter the test subjects all over a depleted and damaged state that finds itself struggling with basic necessities?

It's only intended to be objective inquiry - not fear porn....plus I've been following this study for years now and thought it may be interesting to others

I will try to return later and show you what was changed in their genetic makeup - it is a TRIP
 
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Attachment shows EPA documents relating to the authorization request for experimental use of these "biopesticides"

EPA Report on Modified Mosquitoes

Couple of takeaways for me:

There's a restriction on how close they can release them to homes - people

The Brits didn't fully test whether or not the new mosquitoes could infect arthropods - and possibly transmit new Arbovirus or trigger existing Arbovirus

There ls some moth DNA in there - courtesy of a small company in Lexington, Ky


And - part of the chimeric genetic modification - includes Herpes Simplex-1 Virus

And then they also induce modified pesticides (3 types) with the new male mosquitoes

Page 19 actually acknowledges that there WAS some resistance to the baked in insecticides - actually they saw resistance to TWO of the pesticides that arr supposed to guarantee death of the females)

If you look those up separately - they're generally in commercial use now - one had known side effects if introduced to humans - mildly toxic symptoms of dizziness, and nausea

Page 20 acknowledges that one of the four insecticides used - was "canceled" for use in the US around 2011 - they don't say WHY though -

And page 20 also indicates use of horses blood fm another supplier and "unlikely" - but possible that the females still are capable of transmitting Arbovirus to the human population


Anyway - its all EXPERIMENTAL

The permits are filled with the federal registry, feedback & notifications have occurred - but the research carries a LOT of caveats stating certain outcomes & conditions SHOULD happen or aren't EXPECTED to occur....


Page 18 contains a redacted statement regarding the equine blood the Brits will use to feed the female population of mosquitoes - they need to have females so they can replenish new males gene editing --- and apparently they're using domestic cows blood

^ which they say they're screening continuously - just makes me think of Mad Cow / Hoof-Mouth or Cow-AIDS or whatever

Page 24 indicates there is some expectation of allergic reactions fm humans and possibly some degree of environmental exposures - they don't elaborate on what that could lead to -- because they really don't KNOW



Thats it - know its a lot - but hopefully it's informative & you can see this as objective feedback

Now that I have geeked out and reviewed their research & the permits and some EPA documents - it strikes me as a really FKING UNNECESSARY THING TO DO

The mosquitoes become patented products however (they list their updated species w/corporate code in all docs) -- so they stand to make a lot of money
 
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bigblueinsanity said:
Constantly amazed how experts think they know better than nature. Wish theyd just stop trying to intervene.
Click to expand...

Agreed - but there is a pride and profit factor - and maybe other stuff

Recombinant based vaccines are relatively new - all this modified genetic shit kind of stems fm our genomics research and genetic editing discoveries like CRSPR - all relatively new

Someone came up with the idea of developing an Ebola vaccine -- that is introduced and spread MUCH more quickly - by attaching it to ---->> a RABIES virus

YAY!!!
Hell yeah - hold my beer, feurher -- look what WE can do

Link shows the existence of this type of delivery system:

National Institutes of Health


They're saying the rabies virus has been - you know - made safe - tamed
(Removed the cujo bits)

And the non-infectious RABIES bit is like a smart little speedy viral delivery system--- cause it apparently HAULS ASS through a subjects body - WHICH helps deliver its passenger -- a curious, genetically modified ebola virus


An inactivated, bivalent filovirus/rabies virus vaccine, FILORAB1, consists of recombinant rabies virus virions expressing the Ebola virus glycoprotein. FILORAB1 is immunogenic and protective from Ebola virus challenge in mice and non-human primates,


So - other than that being weirdly interesting and very unsettling - it may become relevant if there's suddenly pressure to take a vaccine for marburg

Marburg is in the same hemmoragic fever family as ebola
This week there were reports of suspected outbreaks in Germany

The WHO almost immediately released a statement about how they've ready to help - test kits? Vaccine distribution maybe?

So - if that picks up steam don't be surprised and don't entertain anyone's suggestion that a precautionary ebola vaccine is a good idea

I DO wonder if WHO will suggest perhaps NOT ENCOURAGING MASS MIGRATION OF HUMAN VECTORS would make sense -
 
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CastleRubric said:
I DO wonder if WHO will suggest perhaps NOT ENCOURAGING MASS MIGRATION OF HUMAN VECTORS would make sense -
Click to expand...
Due to AGW, tropical diseases are spreading. People don't have to migrate because the diseases are coming to people. People are vectors for influenza and measles. The fluids of the dying and the dead are vectors for Ebola. For malaria and Marburg, mosquitos are the vectors.

Nobody needs to encourage the flight to safety. That's built in. People will go where there's safety.
 
CastleRubric said:
Agreed - but there is a pride and profit factor - and maybe other stuff

Recombinant based vaccines are relatively new - all this modified genetic shit kind of stems fm our genomics research and genetic editing discoveries like CRSPR - all relatively new

Someone came up with the idea of developing an Ebola vaccine -- that is introduced and spread MUCH more quickly - by attaching it to ---->> a RABIES virus

YAY!!!
Hell yeah - hold my beer, feurher -- look what WE can do

Link shows the existence of this type of delivery system:

National Institutes of Health


They're saying the rabies virus has been - you know - made safe - tamed
(Removed the cujo bits)

And the non-infectious RABIES bit is like a smart little speedy viral delivery system--- cause it apparently HAULS ASS through a subjects body - WHICH helps deliver its passenger -- a curious, genetically modified ebola virus


An inactivated, bivalent filovirus/rabies virus vaccine, FILORAB1, consists of recombinant rabies virus virions expressing the Ebola virus glycoprotein. FILORAB1 is immunogenic and protective from Ebola virus challenge in mice and non-human primates,


So - other than that being weirdly interesting and very unsettling - it may become relevant if there's suddenly pressure to take a vaccine for marburg

Marburg is in the same hemmoragic fever family as ebola
This week there were reports of suspected outbreaks in Germany

The WHO almost immediately released a statement about how they've ready to help - test kits? Vaccine distribution maybe?

So - if that picks up steam don't be surprised and don't entertain anyone's suggestion that a precautionary ebola vaccine is a good idea

I DO wonder if WHO will suggest perhaps NOT ENCOURAGING MASS MIGRATION OF HUMAN VECTORS would make sense -
Click to expand...

this is smart work, first of all, and these types of approaches are not new. they power many of targeted oncology therapies that are on market.

looks like these researchers ran an interesting experiment and handled the safety concerns properly. poor mice though :(.

doing this for ebola itself is rather niche; marburg is even nichier. ebola has gotten a lot less virulent over time -- likely due to evolutionary pressure: can't propagate if you kill the host too fast. i don't think there is a large commercial need for what these reseachers are proposing.

could be an interesting gambit to repurpose the approach with ace-inhibitors attached. could be an alternative way to stop a heart attack.
 
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