Hard to pick a Final Four because someone always comes out of nowhere.
Here it goes, though:
UK- homer pick. Final Four experience, best starting 5 in the country, IMHO.
Michigan St.- Final Four experience. I think Valentine and Harris will be a dangerous wing combo.
Iowa St.- return most of their stars, a new coach can sometimes rally a team (Michigan '89, UK '98, Illinois '05).
Zona- this could be the year Miller finally gets there with no Kaminsky and Dekker in his way.
But I have better luck picking the 1 seeds. They are more predictable, one game won't determine that:
UK(South)
UNC(East)
Maryland(Midwest)
KU(West)