I would like to see a Goonies 2 movie with most of the original cast brought back. At least Josh Brolin, Sean Astin, Corey Feldman, and the Fratelli brothers (Joe Pantoliano, Robert Davi). They could bring back some of the others as well but I am not sure how many still are acting.
There was talk of doing a sequel but I believe the holdup is trying to get a good story for it. I think a good storyline would be to have a Goonies reunion with them being the adults and bringing their kids back to the old hometown. While there they can tell their kids about their adventure of finding One Eyed Willie's treasure. Sean Astin's character (now a historian type like his father) could tell them he came across another map/clue leading to another treasure and talk the guys into taking their kids on an adventure. Unfortunately for them, the Fratelli brothers are out of prison and looking for a little revenge.
Knowing Hollywood, they would just reboot the original classic and ruin it.