Bound to happen sooner or later, I have seen them on TV in college before but not as the referee. The big step up from a position official to the one in charge is primarily knowledge, I would say, and there are some very smart women.
We had a woman in our high school association over 30 years ago, but she wasn't that good, slow for one thing. But with eight or nine officials in college running fast isn't nearly as important-------you have your segment and things to watch, ever notice the referee still glued to the QB while all the action is somewhere else, or the umpire watching the line play when the RB is about to run over him?
I didn't watch the game but I would say she has to be very good to be a trailblazer.